Clinical characteristics and prognosis of sudden sensorineural hearing loss in single-sided deafness patients

Yupeng Liu; Yupeng Liu; Yupeng Liu; Wenjin Wu; Wenjin Wu; Wenjin Wu; Shuna Li; Shuna Li; Shuna Li; Qing Zhang; Qing Zhang; Qing Zhang; Jingchun He; Jingchun He; Jingchun He; Maoli Duan; Maoli Duan; Jun Yang; Jun Yang; Jun Yang

doi:10.3389/fneur.2023.1230340

Frontiers in Neurology (Sep 2023)

Clinical characteristics and prognosis of sudden sensorineural hearing loss in single-sided deafness patients

Yupeng Liu,
Yupeng Liu,
Yupeng Liu,
Wenjin Wu,
Wenjin Wu,
Wenjin Wu,
Shuna Li,
Shuna Li,
Shuna Li,
Qing Zhang,
Qing Zhang,
Qing Zhang,
Jingchun He,
Jingchun He,
Jingchun He,
Maoli Duan,
Maoli Duan,
Jun Yang,
Jun Yang,
Jun Yang

Affiliations

Yupeng Liu: Department of Otorhinolaryngology-Head & Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Yupeng Liu: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Yupeng Liu: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Wenjin Wu: Department of Otorhinolaryngology-Head & Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Wenjin Wu: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Wenjin Wu: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Shuna Li: Department of Otorhinolaryngology-Head & Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Shuna Li: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Shuna Li: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Qing Zhang: Department of Otorhinolaryngology-Head & Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Qing Zhang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Qing Zhang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Jingchun He: Department of Otorhinolaryngology-Head & Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jingchun He: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jingchun He: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China
Maoli Duan: Ear Nose and Throat Patient Area, Trauma and Reparative Medicine Theme, Karolinska University Hospital, Stockholm, Sweden
Maoli Duan: Division of Ear, Nose and Throat Diseases, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Jun Yang: Department of Otorhinolaryngology-Head & Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
Jun Yang: Shanghai Jiaotong University School of Medicine Ear Institute, Shanghai, China
Jun Yang: Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China

DOI: https://doi.org/10.3389/fneur.2023.1230340
Journal volume & issue: Vol. 14

Abstract

Read online

BackgroundSudden sensorineural hearing loss (SSNHL) in patients with single-sided deafness (SSD) is rare. The prognosis of the sole serviceable hearing ear is very important for these patients. However, the clinical characteristics and prognosis of SSNHL in SSD patients are not well-documented.ObjectiveThis study aimed to investigate the clinical features and treatment outcomes of SSNHL in SSD patients.MethodsClinical data of 36 SSD patients and 116 non-SSD patients with unilateral SSNHL from January 2013 to December 2022 were retrospectively investigated. The clinical characteristics of the SSD patients were analyzed. All SSD patients were treated with intratympanic steroids plus intravenous steroids. Pure-tone average (PTA) and word recognition score (WRS) before and after treatment were recorded. The hearing recovery of SSNHL in SSD patients in comparison with non-SSD patients was explored. Auditory outcomes in SSD patients with different etiologies were also compared.ResultsInitial hearing threshold showed no significant differences between the SSD group and the non-SSD group (66.41 ± 24.64 dB HL vs. 69.21 ± 31.48 dB HL, p = 0.625). The SSD group had a higher post-treatment hearing threshold (median (interquartile range, IQR) 53.13(36.56) dB HL) than the non-SSD group (median 32.50(47.5) dB HL, p < 0.01). Hearing gains (median 8.75(13.00) dB) and the rate of significant recovery (13.89%) were lower in the SSD group than in the non-SSD group (median 23.75(34.69) dB, 45.69%). The etiology of SSD was classified as SSNHL, special types of infection, chronic otitis media, and unknown causes. SSNHL accounted for the maximum proportion (38.9%) of causes of SSD in the SSD group. Hearing gains were lower in the SSNHL-SSD group than in other causes of the SSD group. A binary logistic regression analysis demonstrated that SSD serves as an indicator of unfavorable hearing recovery outcomes (OR = 5.264, p < 0.01).ConclusionThe prognosis of SSNHL in SSD patients is unsatisfactory. SSNHL accounts for the maximum proportion of causes of SSD in this group of patients. For SSD patients caused by SSNHL, less hearing improvement after treatment was expected when SSNHL occurred in the contralateral ear in comparison with SSD patients with other causes.

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

About the journal

Abstract

Keywords