Emerging optofluidic technologies for biodiagnostic applications
Jiandong Wu,
Bo Dai,
Zhenqing Li,
Tingrui Pan,
Dawei Zhang,
Francis Lin
Affiliations
Jiandong Wu
Bionic Sensing and Intelligence Center Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences Shenzhen China
Bo Dai
Engineering Research Center of Optical Instrument and System Ministry of Education Shanghai Key Laboratory of Modern Optical System University of Shanghai for Science and Technology Shanghai China
Zhenqing Li
Engineering Research Center of Optical Instrument and System Ministry of Education Shanghai Key Laboratory of Modern Optical System University of Shanghai for Science and Technology Shanghai China
Tingrui Pan
Department of Biomedical Engineering University of California Davis California USA
Dawei Zhang
Engineering Research Center of Optical Instrument and System Ministry of Education Shanghai Key Laboratory of Modern Optical System University of Shanghai for Science and Technology Shanghai China
Francis Lin
Department of Physics and Astronomy University of Manitoba Winnipeg Manitoba Canada
Abstract The unprecedented global COVID‐19 pandemic strongly argues the critical need for innovative diagnostic tools meeting the requirement of test speed, accuracy, and throughput. Owing to the integration of optics and microfluidics technologies, optofluidic technology enables highly precise flow manipulation and highly sensitive signal detection at the microscale, thus offering the promising potential for developing biodiagnostic applications. Research toward this direction is fast growing into an emerging area. In this paper, we give an overview of emerging optofluidic technologies for biodiagnostic applications with the focus on three common types of biomarkers: nucleic acid, protein, and cell. We conclude by discussing the challenges, opportunities, and future perspectives of this field.
