Structural basis for the second step of group II intron splicing

Russell T. Chan; Jessica K. Peters; Aaron R. Robart; Timothy Wiryaman; Kanagalaghatta R. Rajashankar; Navtej Toor

doi:10.1038/s41467-018-06678-0

Nature Communications (Nov 2018)

Structural basis for the second step of group II intron splicing

Russell T. Chan,
Jessica K. Peters,
Aaron R. Robart,
Timothy Wiryaman,
Kanagalaghatta R. Rajashankar,
Navtej Toor

Affiliations

Russell T. Chan: Department of Chemistry and Biochemistry, University of California, San Diego
Jessica K. Peters: Department of Chemistry and Biochemistry, University of California, San Diego
Aaron R. Robart: Department of Chemistry and Biochemistry, University of California, San Diego
Timothy Wiryaman: Department of Chemistry and Biochemistry, University of California, San Diego
Kanagalaghatta R. Rajashankar: NE-CAT and Department of Chemistry and Chemical Biology, Cornell University, Argonne National Laboratory
Navtej Toor: Department of Chemistry and Biochemistry, University of California, San Diego

DOI: https://doi.org/10.1038/s41467-018-06678-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Group II introns are large, self-splicing RNAs that catalyze their own excision from pre-mRNA molecules. Here the authors determine the 3.7 Å crystal structure of the group II intron in the stage immediately before the second step of splicing and present a complete model for the second step of group II intron splicing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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