Evaluation of cerebrovascular reactivity in moyamoya disease using oxygen-dependent magnetic resonance imaging

Shihao He; Xilong Wang; Hongchuan Niu; Ziqi Liu; Junze Zhang; Xiaokuan Hao; Yanru Wang; Zhenyu Zhou; Yuanli Zhao; Rong Wang

iScience (Feb 2024)

Evaluation of cerebrovascular reactivity in moyamoya disease using oxygen-dependent magnetic resonance imaging

Shihao He,
Xilong Wang,
Hongchuan Niu,
Ziqi Liu,
Junze Zhang,
Xiaokuan Hao,
Yanru Wang,
Zhenyu Zhou,
Yuanli Zhao,
Rong Wang

Affiliations

Shihao He: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
Xilong Wang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Hongchuan Niu: Department of Neurosurgery, Peking University International Hospital, Beijing 102206, China
Ziqi Liu: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Junze Zhang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Xiaokuan Hao: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Yanru Wang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Zhenyu Zhou: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Yuanli Zhao: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Neurosurgery, Peking University International Hospital, Beijing 102206, China; Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China; China National Clinical Research Center for Neurological Diseases, Beijing 100070, China; Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China; Corresponding author
Rong Wang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China; Department of Neurosurgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China; China National Clinical Research Center for Neurological Diseases, Beijing 100070, China; Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing 100069, China; Corresponding author

Journal volume & issue: Vol. 27, no. 2
p. 108923

Abstract

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Summary: Moyamoya disease (MMD) is a rare cerebrovascular disorder marked by progressive stenosis of the internal carotid arteries. Assessing cerebral hemodynamics, specifically cerebrovascular reactivity (CVR), is vital for MMD management and prognosis. In this study, fMRI was performed in a prospective cohort of 47 patients with MMD and 32 healthy controls to investigate its utility in evaluating CVR and to explore the influence of cerebral posterior circulation compensation on CVR in MMD. The regions where the CVR values of participants with MMD were lower than those of healthy controls were primarily concentrated in the frontal, parietal, and temporal lobes (p < 0.05). In certain regions mainly supplied by posterior circulation, the CVR values of compensatory-normal subgroup tended to exceed those of compensatory-poor subgroup. fMRI can detect a significant decrease in CVR values in patients with MMD compared to healthy controls. Compensation for the posterior cerebral circulation may affect cerebrovascular reactivity.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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