Mbnl1 and Mbnl2 regulate brain structural integrity in mice

Naomi S. Sta Maria; Chenyu Zhou; Se Jung Lee; Parvin Valiulahi; Xiandu Li; Jongkyu Choi; Xiaodan Liu; Russell Jacobs; Lucio Comai; Sita Reddy

doi:10.1038/s42003-021-02845-0

Communications Biology (Nov 2021)

Mbnl1 and Mbnl2 regulate brain structural integrity in mice

Naomi S. Sta Maria,
Chenyu Zhou,
Se Jung Lee,
Parvin Valiulahi,
Xiandu Li,
Jongkyu Choi,
Xiaodan Liu,
Russell Jacobs,
Lucio Comai,
Sita Reddy

Affiliations

Naomi S. Sta Maria: Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California
Chenyu Zhou: Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California
Se Jung Lee: Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California
Parvin Valiulahi: Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California
Xiandu Li: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Jongkyu Choi: Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California
Xiaodan Liu: Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California
Russell Jacobs: Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California
Lucio Comai: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Sita Reddy: Department of Biochemistry and Molecular Medicine, Keck School of Medicine, University of Southern California

DOI: https://doi.org/10.1038/s42003-021-02845-0
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

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Sta Maria et al. use 2D MRI to study brains from mice deficient in Mbnl1 and/or Mbnl2 as these Muscleblind-like proteins are thought to play a role in Myotonic Dystrophy Type I (DM1). They show brain region-specific reductions in white and gray matter that could help to explain the variability in the brain structural alterations reported in DM1.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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