Intestinal epithelial cells necroptosis and its association with intestinal inflammation

Abstract

This review focuses on the role of necroptosis, an alternative mode of cell death, in the pathogenesis of diseases associated with intestinal inflammation whose prevalence has been significantly increased for last decades, which substantiates the relevance of this issue. Necroptosis is a programmed necrosis accompanied by the activation of RIPK3 and MLKL kinases. The article covers molecular mechanisms of necroptosis, the role of necroptosis of epithelial intestinal cells in the regulation of intestinal homeostasis, its potential triggers, as well as features of necroptosis during the development of intestinal inflammation. The current review suggests that the development and use of medicines that may target necroptosis-associated kinases seem to be a promising therapeutic strategy.

Keywords

• necroptosis
• cell death
• intestinal epithelial cells
• inflammatory bowel disease
• intestinal inflammation