The pharmacokinetics of aspirin in combination with total ginsenoside of ginseng stems and leaves in rats

Abstract

Objective: To investigate the effect of total ginsenoside of ginseng stems and leaves (TGSL) on the pharmacokinetics of aspirin in rats. Methods: Sprague-Dawley rats were randomly divided into two groups (n = 6), a combined group that received TGSL (625 mg/kg body weight) and aspirin (10 mg/kg body weight) by gavage, and an aspirin group that received aspirin (10 mg/kg body weight) by gavage. The concentration of salicylic acid, an important metabolite of aspirin, was determined by high-performance liquid chromatography in supernatant from blood obtained from the orbital sinus at various time points to examine the effect of TGSL on aspirin. Results: The results showed that the Tmax of salicylic acid was [0.92 (0.58)] hours in the aspirin group and [2.50 (1.22)] hours in the combined group, and was statistically significantly different between the groups (p < .05). Conclusions: TGSL can affect the pharmacokinetics of aspirin at Tmax in rats.

Keywords

• Aspirin
• Total ginsenoside of ginseng stems and leaves (TGSL)
• Pharmacokinetics