Nature Communications (Feb 2020)

Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons

  • Kazuhide Asakawa,
  • Hiroshi Handa,
  • Koichi Kawakami

DOI
https://doi.org/10.1038/s41467-020-14815-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Optogenetic approaches for inducing TDP-43 aggregation have been described previously in cellular models. Here the authors develop an approach to optogenetically induce TDP-43 aggregation in vivo using zebrafish to model ALS pathologies.