Membrane curvature governs the distribution of Piezo1 in live cells

Shilong Yang; Xinwen Miao; Steven Arnold; Boxuan Li; Alan T. Ly; Huan Wang; Matthew Wang; Xiangfu Guo; Medha M. Pathak; Wenting Zhao; Charles D. Cox; Zheng Shi

doi:10.1038/s41467-022-35034-6

Nature Communications (Dec 2022)

Membrane curvature governs the distribution of Piezo1 in live cells

Shilong Yang,
Xinwen Miao,
Steven Arnold,
Boxuan Li,
Alan T. Ly,
Huan Wang,
Matthew Wang,
Xiangfu Guo,
Medha M. Pathak,
Wenting Zhao,
Charles D. Cox,
Zheng Shi

Affiliations

Shilong Yang: Department of Chemistry and Chemical Biology
Xinwen Miao: School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University
Steven Arnold: Department of Cell Biology and Neuroscience
Boxuan Li: Department of Chemistry and Chemical Biology
Alan T. Ly: Department of Physiology & Biophysics, UC Irvine
Huan Wang: Department of Chemistry and Chemical Biology
Matthew Wang: Department of Physics, Rutgers University
Xiangfu Guo: School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University
Medha M. Pathak: Department of Physiology & Biophysics, UC Irvine
Wenting Zhao: School of Chemistry, Chemical Engineering, and Biotechnology, Nanyang Technological University
Charles D. Cox: Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute
Zheng Shi: Department of Chemistry and Chemical Biology

DOI: https://doi.org/10.1038/s41467-022-35034-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

This study demonstrates that the curvature of the cell membrane directly regulates the spatial distribution of Piezo1, a widely expressed mechanosensitive ion channel. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal