Journal of Inflammation Research (Nov 2021)

Long Non-Coding RNAs in Oral Submucous Fibrosis: Their Functional Mechanisms and Recent Research Progress

  • He Y,
  • Wang W,
  • Jiang P,
  • Yang L,
  • Guo Q,
  • Xiang J,
  • Gao Y,
  • Wang Y,
  • Chen R

Journal volume & issue
Vol. Volume 14
pp. 5787 – 5800

Abstract

Read online

Yaodong He,1,* Wei Wang,1,* Pingping Jiang,2 Lin Yang,1 Qi Guo,1 Junwei Xiang,1 Yuling Gao,1 Yuanyin Wang,1 Ran Chen1 1College & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, Anhui Province, 230032, People’s Republic of China; 2School of Pharmacy, Anhui Medical University, Hefei, Anhui Province, 230032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuanyin Wang; Ran ChenCollege & Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, Anhui Province, 230032, People’s Republic of ChinaEmail [email protected]; [email protected]: Many studies have shown that most genomes are transcribed into non-coding RNAs (ncRNAs), including microRNAs (miRs) and long non-coding RNAs (lncRNAs), which can affect different cell characteristics. LncRNAs are long heterologous RNAs that regulate gene expression and various signaling pathways during homeostasis and development. Studies have shown that a lncRNA is an important regulatory molecule that can be targeted to change the physiology and function of cells. Expression or dysfunction of lncRNAs is closely related to various genetic, autoimmune, and metabolic diseases. The importance of ncRNAs in oral submucosal fibrosis (OSF) has garnered much attention in recent years. However, most research has focused on miRs. The role of these molecules in OSF is incompletely understood. This review focuses on the emerging role and function of lncRNAs in OSF as novel regulators. Finally, the potential functional role of lncRNAs as biomarkers for OSF diagnosis is also described. LncRNAs are expected to become a new therapeutic target, but more research is needed to understand their biological functions more deeply.Keywords: oral submucous fibrosis, long non-coding RNAs, function, mechanism, biomarker

Keywords