iScience (Jul 2025)
Application of sentinel lymph nodes biopsy tracers for breast cancer after neoadjuvant chemotherapy in China: A multicenter, real-world study
- Fengjiang Qu,
- Tinghan Jiang,
- Zhenzhen Liu,
- Rui Ling,
- Yi Zhao,
- Hongjian Yang,
- Yunjiang Liu,
- Ke Liu,
- Jianguo Zhang,
- Dahua Mao,
- Jianjun He,
- Zhigang Yu,
- Yinhua Liu,
- Peifen Fu,
- Jiandong Wang,
- Hongchuan Jiang,
- Zuowei Zhao,
- Xingsong Tian,
- Zhongwei Cao,
- Kejin Wu,
- Ailin Song,
- Feng Jin,
- Di Wu,
- Zhimin Fan
Affiliations
- Fengjiang Qu
- Department of Emergency Surgery, The First Hospital of Jilin University, Changchun, Jilin Province 130021, China
- Tinghan Jiang
- Ministry of Education, The First Hospital of Jilin University, Changchun, Jilin Province 130021, China
- Zhenzhen Liu
- Department of Breast Disease, Henan Breast Cancer Center, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan Province 450008, China
- Rui Ling
- Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China
- Yi Zhao
- Surgical Oncology Department, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China
- Hongjian Yang
- Department of Breast Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang Province 310022, China
- Yunjiang Liu
- Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
- Ke Liu
- Fourth Department of Breast Surgery, Jilin Cancer Hospital, Changchun, Jilin Province, China
- Jianguo Zhang
- Department of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150086, China
- Dahua Mao
- Department of Breast Surgery, Affiliated Wudang Hospital of Guizhou Medical University, Guiyang, Guizhou Province 550009, China
- Jianjun He
- Department of Breast Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province 710061, China
- Zhigang Yu
- Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province 250033, China
- Yinhua Liu
- Breast Disease Center, Peking University First Hospital, Beijing 100034, China
- Peifen Fu
- Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China
- Jiandong Wang
- Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100852, China
- Hongchuan Jiang
- Department of Breast Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
- Zuowei Zhao
- Department of Breast Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province 116023, China
- Xingsong Tian
- Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China
- Zhongwei Cao
- Department of Thyroid, Breast, Hernia Surgery, The Inner Mongolia Autonomous Region People’s Hospital, Hohhot, Inner Mongolia Autonomous Region 010017, China
- Kejin Wu
- Department of Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
- Ailin Song
- Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu Province 730000, China
- Feng Jin
- Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning Province, China
- Di Wu
- Department of Breast Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin Province 130021, China; Corresponding author
- Zhimin Fan
- Department of Breast Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin Province 130021, China; Corresponding author
- Journal volume & issue
-
Vol. 28,
no. 7
p. 112889
Abstract
Summary: The real-world application of tracers for axillary sentinel lymph node biopsy (SLNB) for breast cancer (BC) after neoadjuvant chemotherapy (NAC) in China was unknown. We analyzed the use of individual tracers or combinations and number of SLNs in patients with BC who underwent SLNB with or without axillary lymph node dissection (ALND) after NAC in 20 hospitals in ten years. A total of 1251 BC patients underwent SLNB or SLNB + ALND after NAC, including 853 (68.2%, 853/1251) with a single tracer, predominantly Methylene blue (MB) (60.1%, 752/1251); and 398 (31.8%, 398/1251) with dual tracers, mainly MB combined with radioisotope (RI) (18.1%, 226/1251).The results showed that the predominance of the MB single-tracer method for SLNB after NAC limits the popularity of SLNB in patients with BC after NAC in China. MB combined with RI is the main dual-tracer method, and detects SLNs more effectively than MB alone.
