Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

Abstract

Abstract Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx.

Keywords

• Gut-brain-microbiota axis
• Inflammatory
• Inflammatory bowel disease
• Adrenocorticotropic hormone
• Ischemic stroke