Separations (Oct 2021)

Recent Advances on the Development of Chemosensors for the Detection of Mercury Toxicity: A Review

  • Shiva Prasad Kollur,
  • Chandan Shivamallu,
  • Shashanka K. Prasad,
  • Ravindra Veerapur,
  • Sharanagouda S. Patil,
  • Charley A. Cull,
  • Johann F. Coetzee,
  • Raghavendra G. Amachawadi

Journal volume & issue
Vol. 8, no. 192
p. 192


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The harmful impact of mercury on biological systems is of great concern. Regardless of the efforts made by the regulating agencies, a decrease in Hg2+ concentration has not been realized, and hence mercury accumulation in the environment remains of utmost concern. Designing novel and efficient probes for recognition and detection of toxic metals in environmental samples has been of primary importance. Among the available techniques, probe designs involving the study of spectral properties has been preferred because of its obvious ease of instrumentation. Furthermore, occurrence of significant changes in the visible portion of electronic spectra enables detection by the naked eye, thereby endorsing the preference for development of probes with off-on binary responses to aid in the in-field sample analysis. The prominence is further streamlined to the use of fluorescence to help characterize on-response the cellular detection of Hg2+ with ease. In order to overcome the problem of developing efficient probes or sensors bearing fluorescence on-response mechanism that can work effectively in physiological conditions, various methodologies, such as chemo-dosimetric reaction mechanisms for the designing of new luminescent ligands, are being adopted. Additionally, modified charge transfer processes are also being considered for optical detection of the mercury (II) ion. In this review, all such possible techniques have been discussed in detail.