ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1

Tomoya Yamaguchi; Can Lu; Lisa Ida; Kiyoshi Yanagisawa; Jiro Usukura; Jinglei Cheng; Naoe Hotta; Yukako Shimada; Hisanori Isomura; Motoshi Suzuki; Toyoshi Fujimoto; Takashi Takahashi

doi:10.1038/ncomms10060

Nature Communications (Jan 2016)

ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1

Tomoya Yamaguchi,
Can Lu,
Lisa Ida,
Kiyoshi Yanagisawa,
Jiro Usukura,
Jinglei Cheng,
Naoe Hotta,
Yukako Shimada,
Hisanori Isomura,
Motoshi Suzuki,
Toyoshi Fujimoto,
Takashi Takahashi

Affiliations

Tomoya Yamaguchi: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Can Lu: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Lisa Ida: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Kiyoshi Yanagisawa: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Jiro Usukura: Division of Integrated Project, EcoTopia Science Institute, Nagoya University
Jinglei Cheng: Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine
Naoe Hotta: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Yukako Shimada: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Hisanori Isomura: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Motoshi Suzuki: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine
Toyoshi Fujimoto: Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine
Takashi Takahashi: Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine

DOI: https://doi.org/10.1038/ncomms10060
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

Resistance to receptor tyrosine kinase inhibitors is a major obstacle in treatment of lung adenocarcinoma. Yamaguchi et al.identify the orphan receptor ROR1 as a potential target to overcome this resistance, by virtue of its role in promoting cell survival through stabilisation of caveolae.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal