Immunosenescence in Aging-Related Vascular Dysfunction

Abstract

The immunosenescence-related disproportion in T lymphocytes may have important consequences for endothelial dysfunction, which is a key event in vascular aging. The study was designed to assess the prognostic values of the inflammatory-immune profile to better predict and prevent vascular diseases associated with old age. Eighty individuals aged 70.9 ± 5.3 years were allocated to a low- (LGI) or high-grade inflammation (HGI) group based on CRP (2O2, NO, 3-nitrotyrosine, and endothelial progenitor cells (OR 7.61, 95% CI 2.56–29.05, p + and CD8+ between LGI and HGI groups. CRP was 2.5. The odds ratios for the distribution of CD4+ (OR 5.98, 95% CI 0.001–0.008, p + (OR 0.23, 95% CI 0.08–0.59, p + T naïve cells (OR 0.27, 95% CI 0.097–0.695, p p < 0.001) indicated a potential diagnostic value of T lymphocytes for clinical prognosis in aging-related vascular dysfunction.

Keywords

• endothelial progenitor cells
• flow-cytometry
• immune risk profile
• inflammation
• oxidative stress