Клиническая микробиология и антимикробная химиотерапия (Aug 2018)

Aetiology of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation

  • Vasilieva V.A.,
  • Parovichnikova E.N.,
  • Drokov M.Yu.,
  • Kuzmina L.A.,
  • Klyasova G.A.,
  • Tikhomirov D.S.,
  • Tupoleva T.A.,
  • Koroleva O.M.,
  • Dubnyak D.S.,
  • Mikhaltsova E.D.,
  • Popova N.N.,
  • Konova Z.V.,
  • Savchenko V.G.

Journal volume & issue
Vol. 20, no. 3
pp. 232 – 238

Abstract

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Incidence, severity, and risk factors for hemorrhagic cystitis (HC) were assessed in 267 patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). HC was diagnosed in 14.6% (39 patients) within 1-139 days after allo-HSCT (median duration – 39 days). Chemotherapy-related HC was diagnosed in 4 patients only. The majority (19/35) of patients developed late HC of viral aetiology. Median time from a day of HC diagnosis to clinical symptoms resolution was 25 days (range: 6 to 133 days). Using a multivariate analysis, allo-HSCT from mismatched unrelated/haploidentical donor was found to be a risk factor of HC (р=0.01). The analysis also showed that 82.1% of patients with HC received cyclophosphamide as a part of conditioning regimen or +3/+4 days after allo-HSCT.

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