Nature Communications (Nov 2018)
Interethnic analyses of blood pressure loci in populations of East Asian and European descent
- Fumihiko Takeuchi,
- Masato Akiyama,
- Nana Matoba,
- Tomohiro Katsuya,
- Masahiro Nakatochi,
- Yasuharu Tabara,
- Akira Narita,
- Woei-Yuh Saw,
- Sanghoon Moon,
- Cassandra N. Spracklen,
- Jin-Fang Chai,
- Young-Jin Kim,
- Liang Zhang,
- Chaolong Wang,
- Huaixing Li,
- Honglan Li,
- Jer-Yuarn Wu,
- Rajkumar Dorajoo,
- Jovia L. Nierenberg,
- Ya Xing Wang,
- Jing He,
- Derrick A. Bennett,
- Atsushi Takahashi,
- Yukihide Momozawa,
- Makoto Hirata,
- Koichi Matsuda,
- Hiromi Rakugi,
- Eitaro Nakashima,
- Masato Isono,
- Matsuyuki Shirota,
- Atsushi Hozawa,
- Sahoko Ichihara,
- Tatsuaki Matsubara,
- Ken Yamamoto,
- Katsuhiko Kohara,
- Michiya Igase,
- Sohee Han,
- Penny Gordon-Larsen,
- Wei Huang,
- Nanette R. Lee,
- Linda S. Adair,
- Mi Yeong Hwang,
- Juyoung Lee,
- Miao Li Chee,
- Charumathi Sabanayagam,
- Wanting Zhao,
- Jianjun Liu,
- Dermot F. Reilly,
- Liang Sun,
- Shaofeng Huo,
- Todd L. Edwards,
- Jirong Long,
- Li-Ching Chang,
- Chien-Hsiun Chen,
- Jian-Min Yuan,
- Woon-Puay Koh,
- Yechiel Friedlander,
- Tanika N. Kelly,
- Wen Bin Wei,
- Liang Xu,
- Hui Cai,
- Yong-Bing Xiang,
- Kuang Lin,
- Robert Clarke,
- Robin G. Walters,
- Iona Y. Millwood,
- Liming Li,
- John C. Chambers,
- Jaspal S. Kooner,
- Paul Elliott,
- Pim van der Harst,
- The International Genomics of Blood Pressure (iGEN-BP) Consortium,
- Zhengming Chen,
- Makoto Sasaki,
- Xiao-Ou Shu,
- Jost B. Jonas,
- Jiang He,
- Chew-Kiat Heng,
- Yuan-Tsong Chen,
- Wei Zheng,
- Xu Lin,
- Yik-Ying Teo,
- E-Shyong Tai,
- Ching-Yu Cheng,
- Tien Yin Wong,
- Xueling Sim,
- Karen L. Mohlke,
- Masayuki Yamamoto,
- Bong-Jo Kim,
- Tetsuro Miki,
- Toru Nabika,
- Mitsuhiro Yokota,
- Yoichiro Kamatani,
- Michiaki Kubo,
- Norihiro Kato
Affiliations
- Fumihiko Takeuchi
- Medical Genomics Center, National Center for Global Health and Medicine
- Masato Akiyama
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Nana Matoba
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Tomohiro Katsuya
- Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine
- Masahiro Nakatochi
- Data Coordinating Center, Department of Advanced Medicine, Nagoya University Hospital
- Yasuharu Tabara
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Akira Narita
- Tohoku Medical Megabank Organization, Tohoku University
- Woei-Yuh Saw
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Sanghoon Moon
- Division of Genome Research, Center for Genome Science, National Institute of Health
- Cassandra N. Spracklen
- Department of Genetics, University of North Carolina
- Jin-Fang Chai
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Young-Jin Kim
- Division of Genome Research, Center for Genome Science, National Institute of Health
- Liang Zhang
- Singapore Eye Research Institute, Singapore National Eye Centre
- Chaolong Wang
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Huaixing Li
- CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences
- Honglan Li
- State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Jer-Yuarn Wu
- Institute of Biomedical Sciences, Academia Sinica
- Rajkumar Dorajoo
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Jovia L. Nierenberg
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Ya Xing Wang
- Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- Jing He
- Division of Epidemiology, Vanderbilt University Medical Center
- Derrick A. Bennett
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Atsushi Takahashi
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Yukihide Momozawa
- Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences
- Makoto Hirata
- Institute of Medical Science, The University of Tokyo
- Koichi Matsuda
- Graduate School of Frontier Sciences, The University of Tokyo
- Hiromi Rakugi
- Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine
- Eitaro Nakashima
- Division of Endocrinology and Diabetes, Department of Internal Medicine, Nagoya University Graduate School of Medicine
- Masato Isono
- Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine
- Matsuyuki Shirota
- Tohoku Medical Megabank Organization, Tohoku University
- Atsushi Hozawa
- Tohoku Medical Megabank Organization, Tohoku University
- Sahoko Ichihara
- Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine
- Tatsuaki Matsubara
- Department of Internal Medicine, School of Dentistry, Aichi Gakuin University
- Ken Yamamoto
- Department of Medical Biochemistry, Kurume University School of Medicine
- Katsuhiko Kohara
- Faculty of Collaborative Regional Innovation, Ehime University
- Michiya Igase
- Department of Geriatric Medicine, Ehime University Graduate School of Medicine
- Sohee Han
- Division of Genome Research, Center for Genome Science, National Institute of Health
- Penny Gordon-Larsen
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Wei Huang
- Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute (SITI)
- Nanette R. Lee
- USC-Office of Population Studies Foundation, University of San Carlos
- Linda S. Adair
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Mi Yeong Hwang
- Division of Genome Research, Center for Genome Science, National Institute of Health
- Juyoung Lee
- Division of Genome Research, Center for Genome Science, National Institute of Health
- Miao Li Chee
- Singapore Eye Research Institute, Singapore National Eye Centre
- Charumathi Sabanayagam
- Singapore Eye Research Institute, Singapore National Eye Centre
- Wanting Zhao
- Singapore Eye Research Institute, Singapore National Eye Centre
- Jianjun Liu
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Dermot F. Reilly
- Merck Sharp Dohme Corp
- Liang Sun
- CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences
- Shaofeng Huo
- CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences
- Todd L. Edwards
- Division of Epidemiology, Vanderbilt University Medical Center
- Jirong Long
- Division of Epidemiology, Vanderbilt University Medical Center
- Li-Ching Chang
- Institute of Biomedical Sciences, Academia Sinica
- Chien-Hsiun Chen
- Institute of Biomedical Sciences, Academia Sinica
- Jian-Min Yuan
- Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh
- Woon-Puay Koh
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Yechiel Friedlander
- Unit of Epidemiology, Hebrew University-Hadassah Braun School of Public Health
- Tanika N. Kelly
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Wen Bin Wei
- Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- Liang Xu
- Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- Hui Cai
- Division of Epidemiology, Vanderbilt University Medical Center
- Yong-Bing Xiang
- State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine
- Kuang Lin
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Robert Clarke
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Robin G. Walters
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Iona Y. Millwood
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Liming Li
- Chinese Academy of Medical Sciences
- John C. Chambers
- Department of Epidemiology and Biostatistics, Imperial College London
- Jaspal S. Kooner
- National Heart and Lung Institute, Imperial College London
- Paul Elliott
- Medical Research Council-Public Health England (MRC-PHE) Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London
- Pim van der Harst
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- The International Genomics of Blood Pressure (iGEN-BP) Consortium
- Zhengming Chen
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Makoto Sasaki
- Iwate Tohoku Medical Megabank Organization
- Xiao-Ou Shu
- Division of Epidemiology, Vanderbilt University Medical Center
- Jost B. Jonas
- Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- Jiang He
- Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine
- Chew-Kiat Heng
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore
- Yuan-Tsong Chen
- Institute of Biomedical Sciences, Academia Sinica
- Wei Zheng
- Division of Epidemiology, Vanderbilt University Medical Center
- Xu Lin
- CAS Key Laboratory of Nutrition, Metabolism and Food safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences
- Yik-Ying Teo
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- E-Shyong Tai
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Ching-Yu Cheng
- Singapore Eye Research Institute, Singapore National Eye Centre
- Tien Yin Wong
- Singapore Eye Research Institute, Singapore National Eye Centre
- Xueling Sim
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Karen L. Mohlke
- Department of Genetics, University of North Carolina
- Masayuki Yamamoto
- Tohoku Medical Megabank Organization, Tohoku University
- Bong-Jo Kim
- Division of Genome Research, Center for Genome Science, National Institute of Health
- Tetsuro Miki
- Department of Geriatric Medicine, Ehime University Graduate School of Medicine
- Toru Nabika
- Department of Functional Pathology, Shimane University Faculty of Medicine
- Mitsuhiro Yokota
- Department of Genome Science, School of Dentistry, Aichi Gakuin University
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Norihiro Kato
- Medical Genomics Center, National Center for Global Health and Medicine
- DOI
- https://doi.org/10.1038/s41467-018-07345-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, the authors perform discovery GWAS for BP in East Asians and meta-analysis in East Asians and Europeans and report ancestry-specific BP SNPs and selection signals.
