Diabetes, Metabolic Syndrome and Obesity (Jun 2024)
Frequent Self-Monitoring Blood Glucose Correlated to Better Medication Adherence and Glycemic Control in Children with Type 1 Diabetes Mellitus
Abstract
Nur Rochmah,1,2 Soetjipto Soetjipto,3 Muhammad Faizi,1,2 Yuni Hisbiyah,1,2 Rayi Kurnia Perwitasari,1,2 Katherine Fedora,1,2 Laili Nur Rosyidah,4 Endarko Endarko,5 Djoko Kuswanto,6 Eka Agustia Rini7 1Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 2Department of Child Health, Dr. Soetomo General Teaching Hospital, Surabaya, Indonesia; 3Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 4Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; 5Faculty of Science and Data Analysis, Sepuluh Nopember Institute of Technology, Surabaya, Indonesia; 6Faculty of Creative Design and Digital Business, Sepuluh Nopember Institute of Technology, Surabaya, Indonesia; 7Department of Child Health, Faculty of Medicine, Universitas Andalas, Padang, IndonesiaCorrespondence: Soetjipto Soetjipto, Department of Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, Tel +6281331340518, Email [email protected]: Type 1 diabetes mellitus (T1DM) is the most common chronic disease in children, with several severe short and long-term complications. Glycemic control is an important aspect of diabetes management with the most influential factor being compliance with self-monitoring blood glucose (SMBG). Mostly, in Indonesia, the finger stick devices as a glucose monitoring tool were frequently used. About 20% of children follow the recommendation to measure blood glucose four to six times daily.Methods: This is a single center, cross-sectional study that was conducted between July–November 2022. The Population is children with T1DM at the Pediatric Outpatient Clinic of Dr. Soetomo Hospital, Surabaya, Indonesia. Children with T1DM aged 4– 18 years were enrolled using consecutive sampling. A compliance questionnaire was used to assess SMBG. Psychosocial conditions were assessed using the Pediatric Symptom Checklist 17, and medication adherence was evaluated using the Adherence to Refills and Medications Scale for Diabetes (ARMS-D). Pearson correlation and linear regression were employed for statistical analyses using Statistical Package for Social Sciences version 21.0, with p < 0.05 indicating statistical significance.Results: A total of 36 children were included in this study. SMBG frequency over 4x per day was significantly associated with increased medication adherence as measured by the ARMS-D score (p = 0.012). Higher SMBG frequency was also correlated with decreased HbA1c (p = 0.014, r = 0.406) and nutritional status (p = 0.031, r = 0.360). Less than 50% of the patients in Indonesia adhered to the recommended guidelines for SMBG (ie, ≥ 4 times per day).Conclusion: Higher SMBG frequency was correlated with better glycemic control. This finding suggests the need for further support in conducting SMBG based on the national guideline. However, due to it being conducted in a single center, we suggest increasing the sample size or conducting multi-centre collaborations in future studies.Originality/Value: By specifically investigating the relationship between adherence to self-monitoring of blood glucose (SMBG) and glycemic control in children with type 1 diabetes mellitus (T1DM), our study represents a novel contribution to the field of pediatric diabetes management in Indonesia. While previous research has explored similar relationships in other populations, our study focuses exclusively on the unique context of Indonesia, where rates of adherence to SMBG in pediatric patients have not been well studied and are relatively low compared to global standards.Keywords: Diabetes mellitus type-1, medication adherence, glycemic control, HbA1c, children, self-monitoring blood glucose
