Phytosynthesis of Silver Nanoparticle (AgNPs) Using Aqueous Leaf Extract of <i>Knoxia sumatrensis</i> (Retz.) DC. and Their Multi-Potent Biological Activity: An Eco-Friendly Approach
Settu Loganathan,
Kuppusamy Selvam,
Muthugounder Subaramanian Shivakumar,
Sengottayan Senthil-Nathan,
Prabhakaran Vasantha-Srinivasan,
Dhakshinamoorthy Gnana Prakash,
Sengodan Karthi,
Fahad Al-Misned,
Shahid Mahboob,
Ahmed Abdel-Megeed,
Aml Ghaith,
Patcharin Krutmuang
Affiliations
Settu Loganathan
Department of Botany, Periyar University, Salem 636011, Tamil Nadu, India
Kuppusamy Selvam
Department of Botany, Periyar University, Salem 636011, Tamil Nadu, India
Muthugounder Subaramanian Shivakumar
Department of Biotechnology, Periyar University, Periyar Palkalai Nagar, Salem 636011, Tamil Nadu, India
Sengottayan Senthil-Nathan
Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence and Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi 627412, Tamil Nadu, India
Prabhakaran Vasantha-Srinivasan
Department of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai 602105, Tamil Nadu, India
Dhakshinamoorthy Gnana Prakash
Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, Chennai 603110, Tamil Nadu, India
Sengodan Karthi
Department of Entomology, University of Kentucky, Kentucky, KY 40503, USA
Fahad Al-Misned
Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Shahid Mahboob
Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
Ahmed Abdel-Megeed
Department of Plant Protection, Faculty of Agriculture Saba Basha Alexandria University, Alexandria 5452022, Egypt
Aml Ghaith
Department of Zoology, Faculty of Science, Derna University, Derna 20663, Libya
Patcharin Krutmuang
Department of Entomology and Plant Pathology, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50000, Thailand
Green synthesis of silver nanoparticles (AgNPs) has gained greater interest among chemists and researchers in this current scenario. The present research investigates the larvicidal and anti-proliferation activity of AgNPs derived from Knoxia sumatrensis aqueous leaf extract (K. sumatrensis-ALE) as a potential capping and reducing candidate. The synthesized AgNPs were characterized through-UV-spectra absorption peak at 425 nm. The XRD and FT-IR studied displayed the crystalline nature and presence of functional groups in prepared samples. FE-SEM showed the hexagonal shape of NPs with the size of 7.73 to 32.84 nm. The synthesized AgNPs displayed superior antioxidant and anti-proliferative activity (IC50 53.29 µg/mL) of breast cancer cell line (MCF-7). Additionally, larvicidal activity against mosquito vector Culex quinquefasciatus larvae delivered (LC50-0.40, mg/L, and LC90-15.83) significant mortality rate post treatment with synthesized AgNPs. Overall, the present research illustrates that the synthesized AgNPs have high biological potential and present a perfect contender in the pharmacological and mosquitocidal arena.
