Protocol for a systematic review and individual participant data meta-analysis of optimizing oxygen therapy in critically ill patients

Abstract

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BackgroundOxygen therapy is a cornerstone treatment of critically ill patients in the intensive care unit (ICU). Whether lower oxygenation therapy brings superior survival outcomes to higher oxygenation therapy is unknown.MethodsWe will search electronic databases: PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials (CENTRAL), International Clinical Trials Registry Platform (ICTRP), and ClinicalTrials.gov from inception to 1 January 2024. Two authors will independently screen for all eligible clinical studies. Emails will be sent for individual participant data. The statistical analyses will be conducted using STATA 15.0 software.ResultsWe will evaluate the efficacy of lower oxygenation therapy compared with higher oxygenation therapy based on individual participant data.ConclusionThis study will offer clinical evidence for oxygen therapy in ICU patients.

Keywords

• oxygen therapy
• intensive care unit
• meta-analysis
• individual participant data
• systematic review
• protocol