scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory

Keyong Sun; Runda Xu; Fuhai Ma; Naixue Yang; Yang Li; Xiaofeng Sun; Peng Jin; Wenzhe Kang; Lemei Jia; Jianping Xiong; Haitao Hu; Yantao Tian; Xun Lan

doi:10.1038/s41467-022-32627-z

Nature Communications (Aug 2022)

scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory

Keyong Sun,
Runda Xu,
Fuhai Ma,
Naixue Yang,
Yang Li,
Xiaofeng Sun,
Peng Jin,
Wenzhe Kang,
Lemei Jia,
Jianping Xiong,
Haitao Hu,
Yantao Tian,
Xun Lan

Affiliations

Keyong Sun: School of Medicine, Tsinghua University
Runda Xu: School of Medicine, Tsinghua University
Fuhai Ma: Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli
Naixue Yang: School of Medicine, Tsinghua University
Yang Li: Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli
Xiaofeng Sun: School of Medicine, Tsinghua University
Peng Jin: Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli
Wenzhe Kang: Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli
Lemei Jia: School of Medicine, Tsinghua University
Jianping Xiong: Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli
Haitao Hu: Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli
Yantao Tian: Department of Pancreatic and Gastric Surgery, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli
Xun Lan: School of Medicine, Tsinghua University

DOI: https://doi.org/10.1038/s41467-022-32627-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Gastric cancer can vary in tumour stage and immune cell involvement. Here the authors compare gene expression in immune cell types from the blood and the tumour site from GC patients using single cell and TCR sequencing and show that IL17 + CD8 + T cells have a phenotype related to that seen with exhausted cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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