Frontiers in Molecular Neuroscience (May 2017)

Puzzling Out Synaptic Vesicle 2 Family Members Functions

  • Odile Bartholome,
  • Priscilla Van den Ackerveken,
  • Judit Sánchez Gil,
  • Orianne de la Brassinne Bonardeaux,
  • Pierre Leprince,
  • Rachelle Franzen,
  • Bernard Rogister,
  • Bernard Rogister

DOI
https://doi.org/10.3389/fnmol.2017.00148
Journal volume & issue
Vol. 10

Abstract

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Synaptic vesicle proteins 2 (SV2) were discovered in the early 80s, but the clear demonstration that SV2A is the target of efficacious anti-epileptic drugs from the racetam family stimulated efforts to improve understanding of its role in the brain. Many functions have been suggested for SV2 proteins including ions or neurotransmitters transport or priming of SVs. Moreover, several recent studies highlighted the link between SV2 and different neuronal disorders such as epilepsy, Schizophrenia (SCZ), Alzheimer’s or Parkinson’s disease. In this review article, we will summarize our present knowledge on SV2A function(s) and its potential role(s) in the pathophysiology of various brain disorders.

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