Nature Communications (Oct 2019)
TAF1 plays a critical role in AML1-ETO driven leukemogenesis
- Ye Xu,
- Na Man,
- Daniel Karl,
- Concepcion Martinez,
- Fan Liu,
- Jun Sun,
- Camilo Jose Martinez,
- Gloria Mas Martin,
- Felipe Beckedorff,
- Fan Lai,
- Jingyin Yue,
- Alejandro Roisman,
- Sarah Greenblatt,
- Stephanie Duffort,
- Lan Wang,
- Xiaojian Sun,
- Maria Figueroa,
- Ramin Shiekhattar,
- Stephen Nimer
Affiliations
- Ye Xu
- Sylvester Comprehensive Cancer Center, University of Miami
- Na Man
- Sylvester Comprehensive Cancer Center, University of Miami
- Daniel Karl
- Sylvester Comprehensive Cancer Center, University of Miami
- Concepcion Martinez
- Sylvester Comprehensive Cancer Center, University of Miami
- Fan Liu
- Sylvester Comprehensive Cancer Center, University of Miami
- Jun Sun
- Sylvester Comprehensive Cancer Center, University of Miami
- Camilo Jose Martinez
- Sylvester Comprehensive Cancer Center, University of Miami
- Gloria Mas Martin
- Sylvester Comprehensive Cancer Center, University of Miami
- Felipe Beckedorff
- Sylvester Comprehensive Cancer Center, University of Miami
- Fan Lai
- Sylvester Comprehensive Cancer Center, University of Miami
- Jingyin Yue
- Sylvester Comprehensive Cancer Center, University of Miami
- Alejandro Roisman
- Sylvester Comprehensive Cancer Center, University of Miami
- Sarah Greenblatt
- Sylvester Comprehensive Cancer Center, University of Miami
- Stephanie Duffort
- Department of Medicine, Miller School of Medicine, University of Miami
- Lan Wang
- Sylvester Comprehensive Cancer Center, University of Miami
- Xiaojian Sun
- Sylvester Comprehensive Cancer Center, University of Miami
- Maria Figueroa
- Sylvester Comprehensive Cancer Center, University of Miami
- Ramin Shiekhattar
- Sylvester Comprehensive Cancer Center, University of Miami
- Stephen Nimer
- Sylvester Comprehensive Cancer Center, University of Miami
- DOI
- https://doi.org/10.1038/s41467-019-12735-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
AML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal.
