The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts

Frederick Rehfeld; Daniel Maticzka; Sabine Grosser; Pina Knauff; Murat Eravci; Imre Vida; Rolf Backofen; F. Gregory Wulczyn

doi:10.1038/s41467-018-03681-3

Nature Communications (Mar 2018)

The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts

Frederick Rehfeld,
Daniel Maticzka,
Sabine Grosser,
Pina Knauff,
Murat Eravci,
Imre Vida,
Rolf Backofen,
F. Gregory Wulczyn

Affiliations

Frederick Rehfeld: Institute for Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Daniel Maticzka: Department of Computer Science, Albert-Ludwigs-Universität Freiburg
Sabine Grosser: Institute for Integrative Neuroanatomy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Pina Knauff: Institute for Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Murat Eravci: Institute for Chemistry and Biochemistry, Freie Universität Berlin
Imre Vida: Institute for Integrative Neuroanatomy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
Rolf Backofen: Department of Computer Science, Albert-Ludwigs-Universität Freiburg
F. Gregory Wulczyn: Institute for Cell Biology and Neurobiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health

DOI: https://doi.org/10.1038/s41467-018-03681-3
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Many microRNA encoding regions are within introns of other coding genes, and yet the molecular or functional interaction between the two is unclear. This study shows that miR-128′s function is opposed by its host gene ARPP21, and they have complementary effects on neuronal development.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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