Surgical mesh coatings for infection control and temperature sensing: An in-vitro investigation
Shadi Houshyar,
Nedaossadat Mirzadeh,
Mamatha Muraleedharan Pillai,
Tanushree Saha,
Asma Khalid,
Amitava Bhattacharyya,
Chaitali Dekiwadia,
Rumbidzai Zizhou,
Max J. Cryle,
Jennifer A.E. Payne,
Suresh Bhargava,
Kate Fox,
Phong A. Tran
Affiliations
Shadi Houshyar
STEM College, School of Engineering, RMIT University, Melbourne 3001 Australia; Corresponding authors.
Nedaossadat Mirzadeh
The Center for Advanced Materials and Industrial Chemistry, College of Science, Engineering and Health, RMIT University, GPO Box 2476V, Melbourne, Victoria 3001, Australia
Mamatha Muraleedharan Pillai
Tissue Engineering Laboratory, PSG Institute of Advanced Studies, Coimbatore 641004, India
Tanushree Saha
STEM College, School of Engineering, RMIT University, Melbourne 3001 Australia; Department of Textile Engineering, Dhaka University of Engineering and Technology, Gazipur-1707, Gazipur, Bangladesh
Asma Khalid
STEM College, School of Sciences, RMIT University, Melbourne, 3001 Australia
Amitava Bhattacharyya
Functional, Innovative and Smart Textiles, PSG Institute of Advanced Studies, Coimbatore, 641004 India
Chaitali Dekiwadia
RMIT Microscopy and Microanalysis Facility, College of Science, Engineering and Health, RMIT University, Melbourne, 3000 Australia
Rumbidzai Zizhou
School of Fashion and Textiles, RMIT University, Brunswick, Victoria, 3056, Australia
Max J. Cryle
Infection Program, The Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology', Monash University, EMBL Australia, Clayton, Victoria 3800, Australia,
Jennifer A.E. Payne
Infection Program, The Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology', Monash University, EMBL Australia, Clayton, Victoria 3800, Australia,
Suresh Bhargava
The Center for Advanced Materials and Industrial Chemistry, College of Science, Engineering and Health, RMIT University, GPO Box 2476V, Melbourne, Victoria 3001, Australia
Kate Fox
STEM College, School of Engineering, RMIT University, Melbourne 3001 Australia; Corresponding authors.
Phong A. Tran
Centre for Biomedical Technologies, 2 George Street, Queensland University of Technology (QUT), Brisbane, QLD 4000 Australia; Interface Science and Materials Engineering Group, School of Mechanical, Medical and Process Engineering, QUT, 2 George Street, Brisbane, Queensland, 4000 Australia; Corresponding author at: Centre for Biomedical Technologies, 2 George Street, Queensland University of Technology (QUT), Brisbane, QLD 4000 Australia.
Polypropylene (PP) remains the primary material for hernia meshes due to its biocompatibility, physical strength and ease of fabrication. However, PP meshes are still subject to complications such as mesh movement and bacterial infection that ultimately lead to mesh failure. This study describes a two-step functionalization of a PP mesh through dopamine-mediated chloro(triphenylphosphine)gold(I)/nanodiamond coatings. The gold compound provided an intrinsic surface with antimicrobial activity to the coatings, whilst the overall improvement in hydrophilicity and roughness allows for efficient adsorption of antibiotics with an aim for eradicating bacteria in the surrounding tissue. The presence of a gold compound on the surface of the mesh enhanced its contrast property, which may provide a surgical application to determine the ease of monitoring the PP mesh location after implantation inside the body to detect possible tears. Photostable negatively charged nitrogen-vacancy centres within the nanodiamonds provides an exciting possibility to optically assess locally elevated temperatures often associated with infection or excessive inflammation. The biocompatibility, antibiotic loading and associated antimicrobial properties of the coated mesh were investigated to show the potential of this new coating for future applications in hernia surgical procedures.
