Nature Communications (Jun 2016)

Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

  • Tara R. Richman,
  • Henrik Spåhr,
  • Judith A. Ermer,
  • Stefan M. K. Davies,
  • Helena M. Viola,
  • Kristyn A. Bates,
  • John Papadimitriou,
  • Livia C. Hool,
  • Jennifer Rodger,
  • Nils-Göran Larsson,
  • Oliver Rackham,
  • Aleksandra Filipovska

DOI
https://doi.org/10.1038/ncomms11884
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients. Here, the authors characterize mice with a mutation that causes lack of TACO1 expression, identifying a mouse model that could be useful for preclinical trials.