CHARACTERISTICS OF IMMUNE HOMEOSTASIS IN PATIENTS WITH BASAL CELL SKIN CANCER FROM KOPEYSK URBAN DISTRICT

Abstract

Patterns of immune response, cytokine- and NO-ergic mechanisms and their role in the development of basal-cell skin cancer were evaluated in population of an industrialized region. Multiple forms of basal-cell skin cancer and primary multiple cancer were characterized by the evidence of Th2-dependent imbalance of immune response, decreased cytolytic potential, increase of EGF, TGF-β, IL-1β, IL-4, IFNγ, lactoferrin levels, thus suggesting a particular immune defense strategy in malignant growth.

Keywords

• basal-cell skin cancer
• multiple primary cancer
• lymphocyte subsets
• apoptosis
• cytokine profile