GIPR rs10423928 and bone mineral density in postmenopausal women in Shanghai

Abstract

We demonstrated previously that there is a correlation between glucagon-like peptide-1 (GLP-1) single-nucleotide polymorphism (SNP) and bone mineral density in postmenopausal women. Both GLP-1 and glucose-dependent insulinotropic peptide are incretins. The glucose-dependent insulinotropic peptide receptor (GIPR) SNP rs10423928 has been extensively studied. However, it is not clear whether GIPR gene mutations affect bone metabolism. The aim of this study was to investigate the association between rs10423928 and bone mineral density in postmenopausal women in Shanghai. rs10423928 was detected in 884 postmenopausal women in Shanghai, and the c orrelation between the GIPR SNP and bone mineral density was assessed. The dominan t T/T genotype of rs10423928 was found to be related to the bone mineral density of the femoral neck (P = 0.035). Overall, our findings indicate that the dominant T/T ge notype of rs10423928 in postmenopausal women is significantly associated with a higher b one mineral density and that the T/T genotype exerts a bone-protective effect.

Keywords

• osteoporosis
• glucose-dependent insulinotropic peptide
• single-nucleotide polymorphism
• polymorphism
• haplotype
• bone mineral density