Enzyme-like antibacterial activities of Cu9S5 nanoflowers with vacancy-type dependence

Xue Chen; Jing-Hong Wen; Kim Jong Guk; Gui-Zhu Wu; Ze Zhang; Gui-Chang Wang; Ming-Yang Liu; Shu-Hong Yu

Cell Reports Physical Science (Jun 2021)

Enzyme-like antibacterial activities of Cu9S5 nanoflowers with vacancy-type dependence

Xue Chen,
Jing-Hong Wen,
Kim Jong Guk,
Gui-Zhu Wu,
Ze Zhang,
Gui-Chang Wang,
Ming-Yang Liu,
Shu-Hong Yu

Affiliations

Xue Chen: Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
Jing-Hong Wen: Key Laboratory of Advanced Energy Materials Chemistry, Ministry of Education) and the Tianjin Key Lab and Molecule-based Material Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P.R. China
Kim Jong Guk: Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
Gui-Zhu Wu: Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
Ze Zhang: Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
Gui-Chang Wang: Key Laboratory of Advanced Energy Materials Chemistry, Ministry of Education) and the Tianjin Key Lab and Molecule-based Material Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P.R. China; Corresponding author
Ming-Yang Liu: Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China; Department of Civil and Environmental Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA; Corresponding author
Shu-Hong Yu: Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China; Corresponding author

Journal volume & issue: Vol. 2, no. 6
p. 100456

Abstract

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Summary: Due to the increasing drug resistance of bacteria and the limitations of antibacterial nanomaterials through photodynamical and photothermal routes, it is necessary to develop novel nanomaterials with outstanding enzyme-like activities and bacteria-binding capability to produce reactive oxygen species (ROS) to kill bacteria. Herein, we report the synthesis of two kinds of Cu9S5 nanoflowers composed of assemblies of nanosheets, abbreviated as Cu9S5-1 and Cu9S5-2, which possess predominantly VCuSCu and VCuSS vacancies, respectively, as confirmed by the positron annihilation spectra. Both experimental and theoretical calculation results reveal that Cu9S5-2 exhibits excellent enzyme-like activities because of stronger bacteria-binding ability and higher electron affinity that endow it with a superior antibacterial activity compared to Cu9S5-1. This study provides a deeper understanding of nanomaterials with vacancy-type-dependent enzyme-like activities and insights for the rational design of high-performance antibacterial agents in the future.

Published in Cell Reports Physical Science

ISSN: 2666-3864 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Physics
Website: https://www.cell.com/cell-reports-physical-science

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