Determination of coffee extract level in saliva Orthodontic patient

Abstract

Aim: this study was aimed to find out the pharmacokinetic of caffeine (the active compound in coffee) to determine the elimination half-life, area under the curve and other pharmacokinetic parameters for caffeine after excretion in saliva. Materials and Methods: data were collected from twenty orthodontic patients wearing fixed appliance treated in AL Noor center for at least 2 months. Each patient took one cup of coffee (100 ml), then salivary sample was collected at 0, 10, 20, 30, 45 min, 1, 2 and 3 hr. then the concentration of caffeine was detected in every sample. Results: The pharmacokinetic results for caffeine were, elimination rate constant was (0.69hr-1) by NCOMP and (0.69013hr-1) by equation, elimination half-life (1.00hr) and (1.0041hr), volume of distribution (18.17L\kg) and (17.5265L\kg), rate of clearness (10.32 L-1\hr\kg) and (12.0957 L-1\hr\kg), maximum concentration was (15.52 mg) and (15.521 mg). Conclusion: Caffeine pharmacokinetic study shows that caffeine excretes in saliva and has short half-life equal to one hr.

Keywords

• Caffein, Saliva, Pharmacokinetic, Orthodontic patients