Nature Communications (Nov 2022)

Spatially resolved phosphoproteomics reveals fibroblast growth factor receptor recycling-driven regulation of autophagy and survival

  • Joanne Watson,
  • Harriet R. Ferguson,
  • Rosie M. Brady,
  • Jennifer Ferguson,
  • Paul Fullwood,
  • Hanyi Mo,
  • Katherine H. Bexley,
  • David Knight,
  • Gareth Howell,
  • Jean-Marc Schwartz,
  • Michael P. Smith,
  • Chiara Francavilla

DOI
https://doi.org/10.1038/s41467-022-34298-2
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 22

Abstract

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Recruitment of Receptor Tyrosine Kinase signalling partners during endocytosis, specifically during recycling to the plasma membrane, is crucial to signal propagation and regulation. Here, the authors reveal FGFR signalling partners proximal to recycling endosomes with a spatially resolved phosphoproteomics approach.