Revista Brasileira de Ginecologia e Obstetrícia (Jul 2020)

Progress in Local Treatment of Breast Cancer: A Narrative Review

  • Francisco Pimentel Cavalcante,
  • Eduardo Camargo Millen,
  • Felipe Pereira Zerwes,
  • Guilherme Garcia Novita

DOI
https://doi.org/10.1055/s-0040-1712125
Journal volume & issue
Vol. 42, no. 6
pp. 356 – 364

Abstract

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Abstract The present paper reports on the local treatment of breast cancer from a historical perspective. A search for articles written in English was made in the Medline and EMBASE databases, and 40 papers were selected. Over the past 10 years, various randomized, controlled clinical trials on the local treatment of breast cancer indicated that patients with the samemolecular subtypemay receive different individualized surgical treatments aimed atoptimizing systemic adjuvant therapy. With a view to retaining the gainsmade in diseasefree and overall survival, surgical techniques have advanced from radical surgery to conservative mastectomies, thus reducing sequelae, while adjuvant and neoadjuvant therapies have contributed toward controlling the disease, both distant metastases and local recurrence. Current studies evaluate whether future breast cancer therapy may even succeed in eliminating surgery to the breast and axilla altogether.

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