Can Hematological Parameters Predict the Diagnosis of Deep Venous Thrombosis?

Abstract

INTRODUCTION: Although it is known that mean platelet volume (MPV), red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are predictive for arterial trombosis and adverse events, it is not clear whether they help in the diagnosis of deep vein thrombosis. The aim of the study was to evaluate it. For this purpose MPV, RDW, NLR and LMR were measured and compared between in patients with DVT and control groups. METHODS: In a retrospective study, a total of 144 subjects (77 patients with DVT, 67 control) were examined. Mean platelet volume, RDW, NLR and LMR were calculated and compared between the groups. It was investigated whether there was a correlation between D-dimer values and MPV, RDW, NLR, LMR. RESULTS: Mean platelet volume, RDW and NLR values were significantly higher in the patient group than in the control group (9.68+-1.89 vs. 8.9+-1.01, p=0.003, 12.77+-3.67 vs. 11.15+-2.16, p=0.002 and 1.91+-0.84 vs. 1.51+-0.54, p=0.001, respectively). On the other hand LMR was lower in the patient group (6.27+-3.14 vs. 8.85+-3.92, p<0.001). There was a positive correlation between D-dimer and MPV, RDW, NLR while there was a negative correlation between D-dimer and LMR (r=0.693, p<0.001, r=0.896, p<0.001, r=0.798, p<0.001 and r = -0.287, p=0.011, respectively). DISCUSSION AND CONCLUSION: Mean platelet volume, RDW and NLR increase but LMR decrease in patients with DVT. These results suggesting that these markers may help in the diagnosis of acute DVT.

Keywords

• deep venous thrombosis
• mean platelet volume
• red blood cell distribution width
• neutrophil-to-lymphocyte ratio
• lymphocyte-to-monocyte ratio