Scientific Reports (Dec 2023)
Incidence of bacterial and fungal infections in Polish pediatric patients with acute lymphoblastic leukemia during the pandemic
- Joanna Zawitkowska,
- Katarzyna Drabko,
- Monika Lejman,
- Adrian Kowalczyk,
- Krzysztof Czyżewski,
- Magdalena Dziedzic,
- Kamila Jaremek,
- Patrycja Zalas-Więcek,
- Anna Szmydki-Baran,
- Łukasz Hutnik,
- Wojciech Czogała,
- Walentyna Balwierz,
- Iwona Żak,
- Małgorzata Salamonowicz-Bodzioch,
- Bernarda Kazanowska,
- Grażyna Wróbel,
- Jowita Frączkiewicz,
- Krzysztof Kałwak,
- Renata Tomaszewska,
- Tomasz Szczepański,
- Olga Zając-Spychała,
- Jacek Wachowiak,
- Marcin Płonowski,
- Maryna Krawczuk-Rybak,
- Aleksandra Królak,
- Tomasz Ociepa,
- Tomasz Urasiński,
- Filip Pierlejewski,
- Wojciech Młynarski,
- Justyna Urbańska-Rakus,
- Katarzyna Machnik,
- Sonia Pająk,
- Wanda Badowska,
- Tomasz Brzeski,
- Katarzyna Mycko,
- Hanna Mańko-Glińska,
- Agnieszka Urbanek-Dądela,
- Grażyna Karolczyk,
- Agnieszka Mizia-Malarz,
- Weronika Stolpa,
- Katarzyna Skowron-Kandzia,
- Jakub Musiał,
- Radosław Chaber,
- Ninela Irga-Jaworska,
- Ewa Bień,
- Jan Styczyński
Affiliations
- Joanna Zawitkowska
- Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin
- Katarzyna Drabko
- Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin
- Monika Lejman
- Independent Laboratory of Genetic Diagnostics, Medical University of Lublin
- Adrian Kowalczyk
- Student Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin
- Krzysztof Czyżewski
- Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun
- Magdalena Dziedzic
- Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun
- Kamila Jaremek
- Department of Pediatric Hematology and Oncology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun
- Patrycja Zalas-Więcek
- Department of Microbiology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun
- Anna Szmydki-Baran
- Department of Hematology and Pediatrics, Medical University of Warsaw
- Łukasz Hutnik
- Department of Hematology and Pediatrics, Medical University of Warsaw
- Wojciech Czogała
- Department of Pediatric Oncology and Hematology, Intitute of Pediatrics, Jagiellonian University Medical College
- Walentyna Balwierz
- Department of Pediatric Oncology and Hematology, Intitute of Pediatrics, Jagiellonian University Medical College
- Iwona Żak
- Department of Microbiology, University Children’s Hospital, Jagiellonian University Medical College
- Małgorzata Salamonowicz-Bodzioch
- Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University
- Bernarda Kazanowska
- Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University
- Grażyna Wróbel
- Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University
- Jowita Frączkiewicz
- Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University
- Krzysztof Kałwak
- Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Wroclaw Medical University
- Renata Tomaszewska
- Department of Pediatrics, Hematology and Oncology, Medical University of Silesia
- Tomasz Szczepański
- Department of Pediatrics, Hematology and Oncology, Medical University of Silesia
- Olga Zając-Spychała
- Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences
- Jacek Wachowiak
- Department of Pediatric Oncology, Hematology and Transplantology, Poznan University of Medical Sciences
- Marcin Płonowski
- Department of Pediatric Oncology, Hematology, Medical University of Bialystok
- Maryna Krawczuk-Rybak
- Department of Pediatric Oncology, Hematology, Medical University of Bialystok
- Aleksandra Królak
- Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University
- Tomasz Ociepa
- Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University
- Tomasz Urasiński
- Department of Pediatrics, Hemato-Oncology and Gastroenterology, Pomeranian Medical University
- Filip Pierlejewski
- Department of Pediatrics, Oncology and Hematology, Medical University of Lodz
- Wojciech Młynarski
- Department of Pediatrics, Oncology and Hematology, Medical University of Lodz
- Justyna Urbańska-Rakus
- Unit of Pediatric Hematology and Oncology, City Hospital
- Katarzyna Machnik
- Unit of Pediatric Hematology and Oncology, City Hospital
- Sonia Pająk
- Unit of Pediatric Hematology and Oncology, City Hospital
- Wanda Badowska
- Collegium Medicum University of Warmia and Mazury in Olsztyn
- Tomasz Brzeski
- Collegium Medicum University of Warmia and Mazury in Olsztyn
- Katarzyna Mycko
- Collegium Medicum University of Warmia and Mazury in Olsztyn
- Hanna Mańko-Glińska
- Collegium Medicum University of Warmia and Mazury in Olsztyn
- Agnieszka Urbanek-Dądela
- Department of Pediatric Oncology and Hematology, Collegium Medium of Jan Kochanowski University in Kielce
- Grażyna Karolczyk
- Department of Pediatric Oncology and Hematology, Collegium Medium of Jan Kochanowski University in Kielce
- Agnieszka Mizia-Malarz
- Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children’s Care Health, Medical University of Silesia
- Weronika Stolpa
- Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children’s Care Health, Medical University of Silesia
- Katarzyna Skowron-Kandzia
- Department of Oncology, Hematology and Chemotherapy, Upper Silesia Children’s Care Health, Medical University of Silesia
- Jakub Musiał
- Clinic of Pediatric Oncology and Hematology, Faculty of Medicine, University of Rzeszow
- Radosław Chaber
- Clinic of Pediatric Oncology and Hematology, Faculty of Medicine, University of Rzeszow
- Ninela Irga-Jaworska
- Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk
- Ewa Bień
- Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk
- Jan Styczyński
- Student Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin
- DOI
- https://doi.org/10.1038/s41598-023-50093-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 9
Abstract
Abstract The most common complications related to the treatment of childhood acute lymphoblastic leukemia (ALL) are infections. The aim of the study was to analyze the incidence and mortality rates among pediatric patients with ALL who were treated in 17 Polish pediatric hematology centers in 2020–2021 during the pandemic. Additionally, we compared these results with those of our previous study, which we conducted in the years 2012–2017. The retrospective analysis included 460 patients aged 1–18 years with newly diagnosed ALL. In our study, 361/460 (78.5%) children were reported to have microbiologically documented bacterial infections during chemotherapy. Ten patients (2.8%) died due to sepsis. Fungal infections were reported in 99 children (21.5%), of whom five (5.1%) died due to the infection. We especially observed an increase in bacterial infections during the pandemic period compared to the previous study. The directions of our actions should be to consider antibiotic prophylaxis, shorten the duration of hospitalization, and educate parents and medical staff about complications (mainly infections) during anticancer therapy. It is necessary to continue clinical studies evaluating infection prophylaxis to improve outcomes in childhood ALL patients.
