Scientific Reports (Dec 2023)

Incidence of bacterial and fungal infections in Polish pediatric patients with acute lymphoblastic leukemia during the pandemic

  • Joanna Zawitkowska,
  • Katarzyna Drabko,
  • Monika Lejman,
  • Adrian Kowalczyk,
  • Krzysztof Czyżewski,
  • Magdalena Dziedzic,
  • Kamila Jaremek,
  • Patrycja Zalas-Więcek,
  • Anna Szmydki-Baran,
  • Łukasz Hutnik,
  • Wojciech Czogała,
  • Walentyna Balwierz,
  • Iwona Żak,
  • Małgorzata Salamonowicz-Bodzioch,
  • Bernarda Kazanowska,
  • Grażyna Wróbel,
  • Jowita Frączkiewicz,
  • Krzysztof Kałwak,
  • Renata Tomaszewska,
  • Tomasz Szczepański,
  • Olga Zając-Spychała,
  • Jacek Wachowiak,
  • Marcin Płonowski,
  • Maryna Krawczuk-Rybak,
  • Aleksandra Królak,
  • Tomasz Ociepa,
  • Tomasz Urasiński,
  • Filip Pierlejewski,
  • Wojciech Młynarski,
  • Justyna Urbańska-Rakus,
  • Katarzyna Machnik,
  • Sonia Pająk,
  • Wanda Badowska,
  • Tomasz Brzeski,
  • Katarzyna Mycko,
  • Hanna Mańko-Glińska,
  • Agnieszka Urbanek-Dądela,
  • Grażyna Karolczyk,
  • Agnieszka Mizia-Malarz,
  • Weronika Stolpa,
  • Katarzyna Skowron-Kandzia,
  • Jakub Musiał,
  • Radosław Chaber,
  • Ninela Irga-Jaworska,
  • Ewa Bień,
  • Jan Styczyński

DOI
https://doi.org/10.1038/s41598-023-50093-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 9

Abstract

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Abstract The most common complications related to the treatment of childhood acute lymphoblastic leukemia (ALL) are infections. The aim of the study was to analyze the incidence and mortality rates among pediatric patients with ALL who were treated in 17 Polish pediatric hematology centers in 2020–2021 during the pandemic. Additionally, we compared these results with those of our previous study, which we conducted in the years 2012–2017. The retrospective analysis included 460 patients aged 1–18 years with newly diagnosed ALL. In our study, 361/460 (78.5%) children were reported to have microbiologically documented bacterial infections during chemotherapy. Ten patients (2.8%) died due to sepsis. Fungal infections were reported in 99 children (21.5%), of whom five (5.1%) died due to the infection. We especially observed an increase in bacterial infections during the pandemic period compared to the previous study. The directions of our actions should be to consider antibiotic prophylaxis, shorten the duration of hospitalization, and educate parents and medical staff about complications (mainly infections) during anticancer therapy. It is necessary to continue clinical studies evaluating infection prophylaxis to improve outcomes in childhood ALL patients.