Frontiers in Chemistry (Apr 2021)

Methanol-Driven Oxidative Rearrangement of Biogenic Furans – Enzyme Cascades vs. Photobiocatalysis

  • Christina Jäger,
  • Cloé Bruneau,
  • Philip K. Wagner,
  • Martin H. G. Prechtl,
  • Martin H. G. Prechtl,
  • Jan Deska

DOI
https://doi.org/10.3389/fchem.2021.635883
Journal volume & issue
Vol. 9

Abstract

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The oxidative ring expansion of bio-derived furfuryl alcohols to densely functionalized six-membered O-heterocycles represents an attractive strategy in the growing network of valorization routes to synthetic building blocks out of the lignocellulosic biorefinery feed. In this study, two scenarios for the biocatalytic Achmatowicz-type rearrangement using methanol as terminal sacrificial reagent have been evaluated, comparing multienzymatic cascade designs with a photo-bio-coupled activation pathway.

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