EFFECT OF THE ANTHELMINTIC DRUG MITRANOX ON HEMATOLOGICAL AND BIOCHEMICAL VALUES IN THE BLOOD OF RATS IN SUBCHRONIC EXPERIMENT

Abstract

Objective of research: to study the effect of the anthelmintic Mitranox on hematological and biochemical values in the blood of rats. Materials and methods: The experiment was conducted on 40 outbreed male rats divided into 4 groups of 10 rats each. Rats of the first three groups received the drug suspended in 1% starch gel per orally at the doses of 1/5, 1/10 and 1/20 of LD50 (830,4 mg/kg), respectively. Animals of the forth group did not receive the preparation and served as controls. The drug suspension was given to animals daily within 7 days. Animals were slaughtered by resection of jugular vein with the following resection of cervical vertebras. Blood and internal organs of animals were studied according to the standard methods. Results and discussion: When used within 7 days, Mitranox at the doses of 1/5 and 1/10 of LD50 caused the increase in total protein, glucose level, concentration of uric acid in serum, activity of aspartate and alanine aminotransferase and alkaline phosphatase. All this indicated that the drug has a hepatotoxic effect on rats causing the suppression of humoral components of the non-specific immunity. Mitranox at the dose of 1/5 of LD50 has a negative effect on animal pancreas increasing its enzymatic activity.

Keywords

• anthelmintic
• mitranox
• subchronic toxicity
• hematological and biochemical blood values