Acyl-chain saturation regulates the order of phosphatidylinositol 4,5-bisphosphate nanodomains

Abstract

Phosphatidylinositol-4,5-bisphosphates are involved in membrane regulation and signalling in eukaryotes, with the distribution of acyl chains changing in response to stimuli. Here, molecular dynamics simulations and fluorescence spectroscopy experiments show that increasing acyl chain saturation increases the ordering of lipid nanodomains in artificial membranes.