Journal of Laboratory Physicians (Dec 2023)

Effect of ABCA1-R219K Polymorphism in Serum Lipid Parameters in Patients under Statin Therapy Visiting Tertiary Cardiac Center of Nepal

  • Sapana Ghimire,
  • Binod Kumar Yadav,
  • Sweta Shrestha,
  • Jivan Shakya,
  • Chandra Mani Poudel,
  • Eans Tara Tuladhar,
  • Vijay Kumar Sharma,
  • Mithilesh Raut,
  • Aseem Bhattarai,
  • Krishna Das Manandhar,
  • Vivek Pant,
  • Deependra Shrestha

DOI
https://doi.org/10.1055/s-0043-1768630
Journal volume & issue
Vol. 15, no. 04
pp. 510 – 517

Abstract

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Introduction ATP-binding cassette transporter A1 (ABCA1) encoded by ABCA1 gene is one of the important protein involved in lipid metabolism. The effect of statin therapy on dyslipidemia varies among individuals and it may be due to different genetic polymorphism. The R219K polymorphism of ABCA1 gene is found to have a significant role in the response of statin.

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