Neural Regeneration Research (Jan 2015)
Connexin: a potential novel target for protecting the central nervous system?
- Hong-yan Xie,
- Yu Cui,
- Fang Deng,
- Jia-chun Feng
Affiliations
- Hong-yan Xie
- Yu Cui
- Fang Deng
- Jia-chun Feng
- DOI
- https://doi.org/10.4103/1673-5374.155444
- Journal volume & issue
-
Vol. 10,
no. 4
pp. 659 – 666
Abstract
Connexin subunits are proteins that form gap junction channels, and play an important role in communication between adjacent cells. This review article discusses the function of connexins/hemichannels/gap junctions under physiological conditions, and summarizes the findings regarding the role of connexins/hemichannels/gap junctions in the physiological and pathological mechanisms underlying central nervous system diseases such as brain ischemia, traumatic brain and spinal cord injury, epilepsy, brain and spinal cord tumor, migraine, neuroautoimmune disease, Alzheimer′s disease, Parkinson′s disease, X-linked Charcot-Marie-Tooth disease, Pelizaeus-Merzbacher-like disease, spastic paraplegia and maxillofacial dysplasia. Connexins are considered to be a potential novel target for protecting the central nervous system.
Keywords
- spinal cord injury
- propriospinal system
- neural plasticity
- fiber sprouting
- neural repair
- compensation
- regeneration
- propriospinal detours
- neurotrophic factors
- cell-adhesive ligands
- dorsal root ganglia
- L1CAM
- nerve growth factor
- biomaterials
- elastin-like proteins
- Alzheimer′s disease
- AMPK
- apoptosis
- autophagy
- central nervous system
- CCN4
- EGF
- diabetes mellitus
- erythropoietin
- EPO
- FGF
- IGF-1
- mTOR
- neuron
- neuropathy
- oxidative stress
- psychiatric
- stem cells
- WISP1
- Wnt
- peripheral nerve injury
- nerve graft
- nerve conduit
- Wallerian degeneration
- neurotrophic factors
- veins
- autografts
- nerve regeneration
- nerve regeneration
- neuroprotection
- resveratrol
- cerebral ischemia
- cerebral infarction
- matrix metalloproteinase
- molecular docking
- extracellular matrix
- neural regeneration
- nerve regeneration
- vagus nerve stimulation
- cerebral ischemia
- inflammatory cytokines
- infarct volume
- neurological function
- NSFC grants
- neural regeneration
- nerve regeneration
- Xingnao Kaiqiao needling method
- ischemic stroke
- randomized controlled trial
- systemic reviews
- meta-analysis
- long-term efficacy
- mortality
- recurrence
- disability
- adverse reactions
- health economics indicators
- neural regeneration
- nerve regeneration
- DDPH
- cerebral ischemia
- hippocampus
- blood flow
- isolated basilar artery
- dose-response curve
- NSFC grant
- neural regeneration
- nerve regeneration
- traumatic brain injury
- coma
- median nerve electrical stimulation
- wake-promoting
- orexin-A
- OX1R
- NSFC grants
- neural regeneration
- nerve regeneration
- seizure
- antiepileptic drugs
- immature brain
- hippocampus
- synaptic plasticity
- glutamate receptor
- NSFC grant
- neural regeneration
- nerve regeneration
- puerarin
- in vitro experiments
- co-culture
- neurons
- astrocytes
- Transwell
- neonatal rats
- neural regeneration
- nerve regeneration
- brain injury
- inflammatory reaction
- interleukin-6
- voltage-gated Na + channel
- cortical neurons
- cerebrospinal fluid
- neuroimmunomodulation
- neuroprotection
- action potential
- patch clamp
- neurophysiology
- NSFC grants
- neural regeneration
- nerve regeneration
- brain injury
- cognition disorders
- diagnostic techniques
- Wechsler Intelligence Scale
- event-related potential
- neuronal plasticity
- electrophysiology
- neuropsychology
- activity of daily living
- work capacity evaluation
- electroencephalogram
- neural regeneration
- NSFC grant
- nerve regeneration
- cerebral palsy
- corticospinal tract
- diffusion tensor
- hemiplegia
- motor
- rehabilitation
- neural regeneration
- nerve regeneration
- matrix metalloproteinase 9
- cervical and intracranial angioplasty and stenting
- restenosis
- intracranial artery stenosis
- neural regeneration
- nerve regeneration
- bone marrow mesenchymal stem cells
- propofol
- spinal cord injury
- cell transplantation
- electrophysiology
- motor function
- stem cells
- neuroprotection
- neural regeneration
- nerve regeneration
- spinal cord injury
- corticospinal tract
- exercise
- functional recovery
- apoptosis
- Bcl-2
- Bax
- caspase-3
- NSFC grants
- neural regeneration
- nerve regeneration
- human umbilical cord-derived mesenchymal stem cells
- conditioned medium
- Schwann cells
- dorsal root ganglion
- axons
- peripheral nerve regeneration
- neurotrophic factors
- neural regeneration
- connexin
- gap junction
- biosynthetic pathways
- biodegradation
- brain
- central nervous system diseases
