Drug Monitoring by Optically Pumped Atomic Magnetometer

Yi Ruan; Xiang He; Limeng Ruan; Fan Liu; Zhiwen Zhang; Jiaqi Weng; Qinying Yan; Guoyi Zhang; Kan Li; Wenqiang Zheng; Qiang Lin

doi:10.1109/JPHOT.2022.3184050

IEEE Photonics Journal (Jan 2022)

Drug Monitoring by Optically Pumped Atomic Magnetometer

Yi Ruan,
Xiang He,
Limeng Ruan,
Fan Liu,
Zhiwen Zhang,
Jiaqi Weng,
Qinying Yan,
Guoyi Zhang,
Kan Li,
Wenqiang Zheng,
Qiang Lin

Affiliations

Yi Ruan: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Xiang He: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Limeng Ruan: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Fan Liu: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Zhiwen Zhang: College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Jiaqi Weng: College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Qinying Yan: College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Guoyi Zhang: Hangzhou Q-MAG Technology Company, Ltd., Zhejiang University of Technology, Hangzhou, Zhejiang, China
Kan Li: Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Wenqiang Zheng: ORCiD; Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China
Qiang Lin: ORCiD; Zhejiang Provincial Key Laboratory and Collaborative Innovation Center for Quantum Precision Measurement, College of Science, Zhejiang University of Technology, Hangzhou, Zhejiang, China

DOI: https://doi.org/10.1109/JPHOT.2022.3184050
Journal volume & issue: Vol. 14, no. 4
pp. 1 – 5

Abstract

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A novel drug monitoring method is experimentally demonstrated by optically pumped atomic magnetometer. An elliptically polarized single-beam spin-exchange-relaxation-free atomic magnetometer (SERF AM) is used to realize magnetorelaxometry (MRX) measurement and thereby quantify concentrations of superparamagnetic nanoparticles in solutions. Moreover, drug-conjugated magnetic nanoparticles are monitored in mice for twelve hours to study the drug sustained-release mechanism. Our results show the great potential of optically pumped atomic magnetometer for application in biophysical, pharmaceutical and medical areas, and may promote fields such as drug delivery research, virus detection, and molecule quantification.

Published in IEEE Photonics Journal

ISSN: 1943-0655 (Online)
Publisher: IEEE
Country of publisher: United States
LCC subjects: Technology: Engineering (General). Civil engineering (General): Applied optics. Photonics; Science: Physics: Optics. Light
Website: http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=4563994

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