Alzheimer’s Research & Therapy (Mar 2020)

Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

  • Marta Marquié,
  • Sergi Valero,
  • Miguel Castilla-Marti,
  • Joan Martínez,
  • Octavio Rodríguez-Gómez,
  • Ángela Sanabria,
  • Juan Pablo Tartari,
  • Gemma C. Monté-Rubio,
  • Oscar Sotolongo-Grau,
  • Montserrat Alegret,
  • Alba Pérez-Cordón,
  • Natalia Roberto,
  • Itziar de Rojas,
  • Sonia Moreno-Grau,
  • Laura Montrreal,
  • Isabel Hernández,
  • Maitee Rosende-Roca,
  • Ana Mauleón,
  • Liliana Vargas,
  • Carla Abdelnour,
  • Silvia Gil,
  • Ester Esteban-De Antonio,
  • Ana Espinosa,
  • Gemma Ortega,
  • Francisco Lomeña,
  • Javier Pavia,
  • Assumpta Vivas,
  • Miguel Ángel Tejero,
  • Marta Gómez-Chiari,
  • Rafael Simó,
  • Andreea Ciudin,
  • Cristina Hernández,
  • Adelina Orellana,
  • Alba Benaque,
  • Agustín Ruiz,
  • Lluís Tárraga,
  • Mercè Boada,
  • on behalf of the FACEHBI study group

DOI
https://doi.org/10.1186/s13195-020-00602-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Abstract Background Optical coherence tomography (OCT) of the retina is a fast and easily accessible tool for the quantification of retinal structural measurements. Multiple studies show that patients with Alzheimer’s disease (AD) exhibit thinning in several retinal layers compared to age-matched controls. Subjective cognitive decline (SCD) has been proposed as a risk factor for progression to AD. There is little data about retinal changes in preclinical AD and their correlation with amyloid-β (Aβ) uptake. Aims We investigated the association of retinal thickness quantified by OCT with Aβ accumulation and conversion to mild cognitive impairment (MCI) over 24 months in individuals with SCD. Methods One hundred twenty-nine individuals with SCD enrolled in Fundació ACE Healthy Brain Initiative underwent comprehensive neuropsychological testing, OCT scan of the retina and florbetaben (FBB) positron emission tomography (PET) at baseline (v0) and after 24 months (v2). We assessed the association of sixteen retinal thickness measurements at baseline with FBB-PET status (+/−) and global standardize uptake value ratio (SUVR) as a continuous measure at v0 and v2 and their predictive value on clinical status change (conversion to mild cognitive impairment (MCI)) at v2. Results Mean age of the sample was 64.72 ± 7.27 years; 62.8% were females. Fifteen participants were classified as FBB-PET+ at baseline and 22 at v2. Every 1 μm of increased thickness in the inner nasal macular region conferred 8% and 6% higher probability of presenting a FBB-PET+ status at v0 (OR = 1.08, 95% CI = 1.02–1.14, p = 0.007) and v2 (OR = 1.06, 95% CI = 1.02–1.11, p = 0.004), respectively. Inner nasal macular thickness also positively correlated with global SUVR (at v0: β = 0.23, p = 0.004; at v2: β = 0.26, p = 0.001). No retinal measurements were associated to conversion to MCI over 24 months. Conclusions Subtle retinal thickness changes in the macular region are already present in SCD and correlate with Aβ uptake.

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