Nature Communications (Apr 2021)
DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death
- Heng Boon Low,
- Zhen Lim Wong,
- Bangyuan Wu,
- Li Ren Kong,
- Chin Wen Png,
- Yik-Lam Cho,
- Chun-Wei Li,
- Fengchun Xiao,
- Xuan Xin,
- Henry Yang,
- Jia Min Loo,
- Fiona Yi Xin Lee,
- Iain Bee Huat Tan,
- Ramanuj DasGupta,
- Han-Ming Shen,
- Herbert Schwarz,
- Nicholas R. J. Gascoigne,
- Boon Cher Goh,
- Xiaohong Xu,
- Yongliang Zhang
Affiliations
- Heng Boon Low
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Zhen Lim Wong
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Bangyuan Wu
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Li Ren Kong
- Cancer Science Institute of Singapore, National University of Singapore
- Chin Wen Png
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Yik-Lam Cho
- Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
- Chun-Wei Li
- Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-Sen University
- Fengchun Xiao
- Department of Pathology, The First Affiliated Hospital of Zhejiang Chinese Medical University
- Xuan Xin
- Department of Mathematics, National University of Singapore
- Henry Yang
- Cancer Science Institute of Singapore, National University of Singapore
- Jia Min Loo
- Genome Institute of Singapore, Agency of Science Technology and Research (A*Star)
- Fiona Yi Xin Lee
- Division of Medical Oncology, National Cancer Center
- Iain Bee Huat Tan
- Division of Medical Oncology, National Cancer Center
- Ramanuj DasGupta
- Genome Institute of Singapore, Agency of Science Technology and Research (A*Star)
- Han-Ming Shen
- Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
- Herbert Schwarz
- Immunology Programme, the Life Science Institute, National University of Singapore
- Nicholas R. J. Gascoigne
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- Boon Cher Goh
- Cancer Science Institute of Singapore, National University of Singapore
- Xiaohong Xu
- Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University
- Yongliang Zhang
- Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore
- DOI
- https://doi.org/10.1038/s41467-021-22638-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Chemoresistance is one of the main challenges for cancer therapy success. Here, the authors show that dual-specificity phosphatase 16 (DUSP16) expression is associated with chemoresistance in several types of cancer through impairing mitochondria-associated apoptosis.
