Nature Communications (Apr 2018)
HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis
- Margaux Sevin,
- Lucia Kubovcakova,
- Nicolas Pernet,
- Sébastien Causse,
- Franck Vitte,
- Jean Luc Villeval,
- Catherine Lacout,
- Marine Cordonnier,
- Fernando Rodrigues-Lima,
- Gaétan Chanteloup,
- Matthieu Mosca,
- Marie-Lorraine Chrétien,
- Jean Noël Bastie,
- Sylvain Audia,
- Paul Sagot,
- Selim Ramla,
- Laurent Martin,
- Martin Gleave,
- Valérie Mezger,
- Radek Skoda,
- Isabelle Plo,
- Carmen Garrido,
- François Girodon,
- Aurélie de Thonel
Affiliations
- Margaux Sevin
- University of Bourgogne Franche-Comté
- Lucia Kubovcakova
- Department of Biomedicine, Experimental Hematology, University Hospital Basel
- Nicolas Pernet
- University of Bourgogne Franche-Comté
- Sébastien Causse
- University of Bourgogne Franche-Comté
- Franck Vitte
- Cypath
- Jean Luc Villeval
- University Paris XI, UMR 1170, Gustave Roussy
- Catherine Lacout
- University Paris XI, UMR 1170, Gustave Roussy
- Marine Cordonnier
- University of Bourgogne Franche-Comté
- Fernando Rodrigues-Lima
- Universite Paris Diderot, Sorbonne Paris Cite, Unite BFA, CNRS UMR 8251
- Gaétan Chanteloup
- University of Bourgogne Franche-Comté
- Matthieu Mosca
- University Paris XI, UMR 1170, Gustave Roussy
- Marie-Lorraine Chrétien
- Hospital University Center (CHU)
- Jean Noël Bastie
- University of Bourgogne Franche-Comté
- Sylvain Audia
- Hospital University Center (CHU)
- Paul Sagot
- Hospital University Center (CHU)
- Selim Ramla
- Hospital University Center (CHU)
- Laurent Martin
- Hospital University Center (CHU)
- Martin Gleave
- The Vancouver Prostate Centre, University of British Columbia
- Valérie Mezger
- CNRS, UMR7216 Épigénétique et Destin Cellulaire
- Radek Skoda
- Department of Biomedicine, Experimental Hematology, University Hospital Basel
- Isabelle Plo
- University Paris XI, UMR 1170, Gustave Roussy
- Carmen Garrido
- University of Bourgogne Franche-Comté
- François Girodon
- University of Bourgogne Franche-Comté
- Aurélie de Thonel
- University of Bourgogne Franche-Comté
- DOI
- https://doi.org/10.1038/s41467-018-03627-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Myelofibrosis is a chronic degenerative disorder characterized by progressive bone marrow fibrosis. Here, the authors show that the chaperone HSP27 contributes to myelofibrosis via regulation of the JAK2/STAT5 pathway, and that antisense oligonucleotides targeting HSP27 are effective in two mouse models of the disease
