P1551: CONFORMATIONAL STUDY OF PYRUVATE KINASE DEFICIENT VARIANTS WITH HEMOLYTIC ANEMIA. THE RELATIONSHIPS BETWEEN THE LOSS OF ENZYME FUNCTION AND STRUCTURAL DISRUPTION

• L. Jorda,
• L. Montllor,
• E. Krisnevskaya,
• V. Leguizamón,
• I. Hernandez,
• J. L. Gelpi,
• J.-L. Vives Corrons

Affiliations

L. Jorda

1 Supercomputing Center, BSC, Barcelona

L. Montllor

2 Red Blood Cell and Hematopoietic Disorders, Josep Carreras Leukaemia Research Institute (IJC)

E. Krisnevskaya

2 Red Blood Cell and Hematopoietic Disorders, Josep Carreras Leukaemia Research Institute (IJC)

V. Leguizamón

2 Red Blood Cell and Hematopoietic Disorders, Josep Carreras Leukaemia Research Institute (IJC)

I. Hernandez

3 Hematology Department, ICO-Hospital Universitari Germans Trias i Pujol, Badalona

J. L. Gelpi

4 Dept. Biochemistry and Molecular Biomedicine, University of Barcelona, Barcelona, Spain

J.-L. Vives Corrons

2 Red Blood Cell and Hematopoietic Disorders, Josep Carreras Leukaemia Research Institute (IJC)