Levels of Type IIA Phospholipase A2 and Type IV Collagen in Patients with Chronic Alcoholic Pancreatitis Associated with Liver Cirrhosis Class A, B by Child-Pugh

Abstract

In 49 patients, of whom 20 were diagnosed with combined lesions of the pancreas (chronic pancreatitis in the acute stage) and liver (cirrhosis class A, B by Child-Pugh) of alcoholic origin, 12 — with exacerbation of chronic pancreatitis without concomitant pathology, and 17 — with alcoholic cirrhosis of the same stage without involving in the process of the pancreas, we have determined the concentrations of type IIA phospholipase A2 and type IV collagen levels in the blood serum. The highest levels of type IIA phospholipase A2 were identified in patients with combined alcohol-induced pancreatic and liver injuries (568.57 ± 30.34 pg/ml), which is 1.58 times higher than its level in patients with isolated alcohol-induced pancreatic injury (P < 0.05). In patients with alcoholic cirrhosis class A by Child-Pugh, concentration of type IIA phospholipase A2 was (171.35 ± 22.46) pg/ml (in healthy peop­le — (123.00 ± 10.12) pg/ml). According to the prescription of combined injury of the pancreas and liver (over 5 years), the level of type IIA phospholipase A2 decreased, whereas type IV collagen concentration increased 2.5 times compared with that of in patients with disease duration up to one year, and between them a moderate inverse correlation was detected.

Keywords

• chronic alcoholic pancreatitis
• alcoholic liver cirrhosis
• type IIA phospholipase A2
• collagen type IV