Patients with arterial hypertension associated with metabolic disorders: characteristics and therapeutic approach

Abstract

Arterial hypertension (AH) is associated with metabolic disorders in approximately 80% of cases. There is a pandemic of so-called new risk factors, such as insulin resistance and association with systemic type of hyperinsulinemia, abdominal obesity, hyperinsulinemia and a special type of dislipidemy, nowadays. Patients with AH associated with such metabolic disorders are at a higher risk of developing cardiovascular disease and diabetes. However, it is very difficult to achieve the target level of blood pressure in this category of patients. Usually, these patients should be treated using combination therapy at the beginning of the treatment. Drugs, which possess good antihypertensive effect, as well as an additional positive influence on metabolic parameters, for instance I2-imidazoline receptor agonists, can be used as the drugs of choice in combination with ACE inhibitorsor angiotensin II receptor blockersin this category of patients.

Keywords

• arterial hypertension
• diabetes mellitus
• metabolic syndrome
• combination therapy
• moxonidine