The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview

Esma Mouhoub; Esma Mouhoub; Esma Mouhoub; Pilar Domenech; Pilar Domenech; Momar Ndao; Momar Ndao; Momar Ndao; Momar Ndao; Momar Ndao; Michael B. Reed; Michael B. Reed; Michael B. Reed; Michael B. Reed

doi:10.3389/fmicb.2021.757858

Frontiers in Microbiology (Oct 2021)

The Diverse Applications of Recombinant BCG-Based Vaccines to Target Infectious Diseases Other Than Tuberculosis: An Overview

Esma Mouhoub,
Esma Mouhoub,
Esma Mouhoub,
Pilar Domenech,
Pilar Domenech,
Momar Ndao,
Momar Ndao,
Momar Ndao,
Momar Ndao,
Momar Ndao,
Michael B. Reed,
Michael B. Reed,
Michael B. Reed,
Michael B. Reed

Affiliations

Esma Mouhoub: The Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada
Esma Mouhoub: The Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Esma Mouhoub: The McGill International TB Centre, McGill University, Montreal, QC, Canada
Pilar Domenech: The Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Pilar Domenech: The McGill International TB Centre, McGill University, Montreal, QC, Canada
Momar Ndao: The Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada
Momar Ndao: The Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Momar Ndao: The McGill International TB Centre, McGill University, Montreal, QC, Canada
Momar Ndao: The Department of Medicine, McGill University, Montreal, QC, Canada
Momar Ndao: National Reference Centre for Parasitology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Michael B. Reed: The Department of Microbiology & Immunology, McGill University, Montreal, QC, Canada
Michael B. Reed: The Infectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Michael B. Reed: The McGill International TB Centre, McGill University, Montreal, QC, Canada
Michael B. Reed: The Department of Medicine, McGill University, Montreal, QC, Canada

DOI: https://doi.org/10.3389/fmicb.2021.757858
Journal volume & issue: Vol. 12

Abstract

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Live attenuated Bacillus Calmette-Guérin (BCG) is the world’s most widely used vaccine which is mainly administered for its protection against tuberculosis (TB), particularly in young children. However, since its initial use over 100years ago, it has also proven to offer a level of protection against various other pathogens, as a consequence of its non-specific immune enhancing effects. Thus, over the past few decades, recombinant BCG (rBCG) technology has been used as a vector to create rBCG vaccines expressing heterologous antigens that elicit immunity against a range of bacterial, viral, and parasitic diseases. Our goal with this mini-review is to provide an up-to-date survey of the various techniques, approaches, and applications of rBCG-based vaccines for targeting infectious diseases other than TB.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

About the journal

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