The role of the ceRNA network mediated by lncRNA SNHG3 in the progression of cancer

Abstract

Abstract Background Long non-coding RNAs (lncRNAs) are a distinct class of RNAs with longer than 200 base pairs that are not translated into proteins. Small Nucleolar RNA Host Gene 3 (SNHG3) is a lncRNA and frequently dysregulated in various human cancers. Objective This review provides a comprehensive analysis of current research on lncRNA SNHG3, focusing on its role within the competitive endogenous RNA (ceRNA) network and its implications in cancer. Methods A systematic literature review was conducted using PubMed up to October 2023. The search strategy included keywords such as “lncRNA SNHG3”, “competitive endogenous RNA”, “cancer”, and related terms. Studies were selected based on relevance to SNHG3's involvement in cancer pathogenesis and progression. Results Disruptions in the ceRNA network involving lncRNA SNHG3 can impair normal cell growth and differentiation, significantly contributing to disease pathogenesis, particularly cancer. This review highlights SNHG3's substantial impact on various cancer processes and its potential as a diagnostic and therapeutic tool for aggressive cancers. Conclusion The findings underscore SNHG3's pivotal role in cancer prevention, diagnosis, and treatment, laying a foundation for future research in cancer management. Insights from this review emphasize the necessity for further exploration and development of SNHG3-based diagnostic and therapeutic strategies.

Keywords

• Long non-coding RNA
• Competitive endogenous RNAs
• Tumorigenesis biomarker,
• Potential therapeutic target,
• LncRNA SNHG3,
• Human cancer