Communications Medicine (Jan 2023)
Serum biomarker-based early detection of pancreatic ductal adenocarcinomas with ensemble learning
- Nuno R. Nené,
- Alexander Ney,
- Tatiana Nazarenko,
- Oleg Blyuss,
- Harvey E. Johnston,
- Harry J. Whitwell,
- Eva Sedlak,
- Aleksandra Gentry-Maharaj,
- Sophia Apostolidou,
- Eithne Costello,
- William Greenhalf,
- Ian Jacobs,
- Usha Menon,
- Justin Hsuan,
- Stephen P. Pereira,
- Alexey Zaikin,
- John F. Timms
Affiliations
- Nuno R. Nené
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- Alexander Ney
- Institute for Liver and Digestive Health, University College London
- Tatiana Nazarenko
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- Oleg Blyuss
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- Harvey E. Johnston
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- Harry J. Whitwell
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- Eva Sedlak
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- Aleksandra Gentry-Maharaj
- MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology
- Sophia Apostolidou
- MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology
- Eithne Costello
- Department of Molecular and Clinical Cancer Medicine, University of Liverpool
- William Greenhalf
- Liverpool Experimental Cancer Medicine Centre, University of Liverpool
- Ian Jacobs
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- Usha Menon
- MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology
- Justin Hsuan
- Institute for Liver and Digestive Health, University College London
- Stephen P. Pereira
- Institute for Liver and Digestive Health, University College London
- Alexey Zaikin
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- John F. Timms
- Department of Women’s Cancer, EGA Institute for Women’s Health, University College London
- DOI
- https://doi.org/10.1038/s43856-023-00237-5
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 1 – 14
Abstract
Nené et al. construct machine learning models based on serum protein biomarker data to detect pancreatic ductal adenocarcinoma in a nested case-control study from the UKCTOCS cohort. Their ensemble modelling approach outperforms existing combinations of biomarkers.
