Nature Communications (Feb 2021)

Blood-brain barrier opening with focused ultrasound in Parkinson’s disease dementia

  • Carmen Gasca-Salas,
  • Beatriz Fernández-Rodríguez,
  • José A. Pineda-Pardo,
  • Rafael Rodríguez-Rojas,
  • Ignacio Obeso,
  • Frida Hernández-Fernández,
  • Marta del Álamo,
  • David Mata,
  • Pasqualina Guida,
  • Carlos Ordás-Bandera,
  • J. Ignacio Montero-Roblas,
  • Raúl Martínez-Fernández,
  • Guglielmo Foffani,
  • Itay Rachmilevitch,
  • José A. Obeso

DOI
https://doi.org/10.1038/s41467-021-21022-9
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 7

Abstract

Read online

Blood brain barrier (BBB) opening is being investigated as a therapeutic approach for neurodegenerative diseases. Here, the authors report the results of a phase I trial to evaluate the feasibility and safety of BBB opening of the right parieto-occipito-temporal cortex in Parkinson´s disease with dementia.